My favorite restaurant in Tampa is the original Columbia Restaurant in Ybor City. Take the wife for a nice dinner (get the 1905 salad) then do a little bar hopping in Ybor; just avoid the hip hop bars on the other side of the street.
Shooter's World is a big gun store in west Tampa. They have a small museum area with some cool stuff. Definitely worth a visit.
International Mall in Tampa (by the airport) has a cool restaurant/bar area and high end stores. Brandon (east of Tampa) is a big suburbia shopping area.
Lot's to do in the Tampa/Clearwater/St Pete area depending on what you like: beach, fishing, golf, etc.
Orlando is a short drive from Tampa also, if you wanted to hit up some of the attractions.