Lots of nice shops and cafes right there along Main St. Definitely visit MAST General store on Main St. If you want to try pork Barbeque instead of the beef kind you are probably used to go to Henry's Smoke House not to far away near where Stone Ave and Wade Hampton Blvd meet. A really good gun store is Palmetto State Armory on Woodruff Road, near I-85. If you want some really good upscale dining, visit Rick Erwins restaurant on the south end of Main St. There is actually a Confederate Museum in Greenville not far from where you are staying. There is also a baseball stadium very near the south end of Main St where the Greenville Drive baseball team plays if the happen to be playing while you are there, and Clemson University is only about a 35 or 40 minute drive away. They have an excellent college baseball team and nice stadium. If you want real authentic Greek Food, you have got to try the Pita House on South Pleasantburg Drive near where Farris Rd intersects. Another good locals place is The Blockhouse on Augusta Rd.
HTH