Just out of curiosity, have you hunted Texas deer with a .223? Are you happy with it? If you haven't, why experiment on an expensive out-of-state hunting trip? Bring something you have confidence in.
To answer your question:
I know a few people who have used .223/5,56 from blinds at close range, like at stock ponds. At 300 yards, a 55-grain .223 Remington round has as much energy as a 22 Magnum rimfire at the muzzle. A 64 grain bullet will have a bit more energy, but is your hunting style compatible with a limited effective range? It's tempting to "go long" out on the open prairie. In addition, Pronghorn are basically cardiovascular systems on legs. They can be surprisingly hardy.
I'd suggest using the Federal Fusion or Fusion MSR loads. Generic JSP ammo may shed the jacket too early and leave you with a long walk. For handloading, I'd look at a Barnes hunting bullet or the Nosler bonded solid base bullet.
Have fun!