I have a T22 from Huntertown Arms, a Spectre II, and a Mist TD (in jail).
I'm going against the grain and saying integral. The Spectre lives in a Savage bolt, and (obviously) my other two live on their 10/22 hosts.
When I shoot pistols, I normally shoot 9mm or .45, not .22 LR. Further more, in my experience, I tend to favor one host for each supressor.
Almost 100% of my .45ACP is shot through one of my 1911s. My g21 is threaded, it just doesn't get used.
My XDM is threaded, but I always seem to use my G17.
My buddy has a threaded 10/22, but we hardly supress that because of my T22, (and soon enough, my Mist TD)
It definitely adds versatility, but I've found I never use that versatility. I tend to favor a setup, and continue to use it. That's why integral .22 cans are my personal favorite.
I still love me some Spectre, and I'm dying to try a Mask, but man integrals are cool and fun.