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Beyond a life threatening situation ( at which point who cares if you wreck the gun) there is never any use to running plus p at all
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There is merit to training with your carry ammo.
There is a common misconception that an "adrenaline dump" at the moment of truth will magically make it all happen and such...but if anything that makes things harder. That will not improve your technique, form, or accuracy. Most often high stress will degrade ones skills to their lowest level, not highest.
Do as you choose, but a DS is more likely to go out of time from regular practice than get shaken loose from occasional +p use.
As an aside, most Cobras and Agents I see are in better shape mechanically because folks shoot them less. Colt used to advise that the alloy guns should be serviced after 1000 rounds of +p and the steel guns after 3000.