"Now, given that Colt no longer services second generation SAAs am I going to have issues putting .357 through this gun? I have heard pythons had this issue which is why I'm asking."
I'm not sure what "issues" with shooting .357 in either the SAA or the Python you've heard.
The only issues with this is that after firing .38 Special ammo in a .357 revolver you need to use a bronze chamber cleaning brush to clean the fouling of the .38 Special out of the chambers before using .357.
The shorter .38 ammo will leave fouling build up in the chambers and the .357 may not chamber easily.
Other than that, there are no issues with using .357 in a revolver chambered in .357.
The only safe way to carry a SAA is with an empty chamber under the hammer. The "safety" notch is not that strong and if you drop the gun or manage to hit the hammer, the trigger or hammer notch can be broken and the gun will fire.
This has been known since 1873, and it's still valid today with original type design single action revolvers.