As long as you are comfortable with it, that's all that matters and have at it.
At the PD I work for, we are subject to 24/7 callouts if the on duty Officer needs help due to budget cuts and cutting the number of Officers working a shift. We are now down to 1 Officer from 0300-2100, then two from 2100-0300. On the weekends (Fri and Sat nights), if we can find a part timer to work, we usually have another Officer from 1700-0300. This is for a town of about 5000. Needless to say, we are often REAL BUSY on a shift!
I started out carrying my Sig P226 on and off duty and quickly found it to be too bulky for off duty. Tried various guns- S&W M6906, HK P7M8, Glock 26 (carried by far the longest), S&W M649 (one of the early .357 guns with no lock), Ruger SP101. Liked either the M649 or SP101 best. When the budget cuts hit, I really didn't feel like running towards the sound of the guns with a 5 shot snubbie if called out, so I went back to the G26 and now carry a Shield 9mm. I can shoot the Shield as well as my G22 duty gun with the extended 8 rd mag and almost as well with the standard 7 rd mag, as well as the advantages of quick reloads if necessary, so I'm happy.
If I wasn't subject to callout and only had to worry about self defense, I would probably be carrying the M649 again. Shoots like a dream with Dept mandated .38+P, heavy enough to soak up a lot of recoil but light enough for comfortable carry. Not a pocket carry gun with the steel frame, by any means, but IWB is effortless. Not to mention, I really like DA revolvers. The only thing keeping me from doing it now is that I really don't want to have to go running towards an armed guy(s) with just a 5 shot snubbie. I still have both the M649 and SP101 and, upon retirement, when all I have to worry about is myself again, one of them may well come back out to play. We'll have to see how it works out.
Bub75