The AR-15 lower is well standardized, so if you get one, you can do anything with it that's possible with an AR-15. BATFE regulations require manufacturers to mark "the firearm" (which is the lower in the case of the AR-15) with a caliber, but that doesn't mean you're limited to that caliber - and many lower manufacturers mark their parts "MULTI" rather than with a specific caliber. It really doesn't matter at all.
When you build your lower, you'll have lots of choices for the bits/parts/pieces. One important choice is what kind of stock you want to put on it. You can go with a "rifle" type stock or a "carbine" type stock. The rifle stock works with a standard rifle receiver extension (often called the "buffer tube" - which is imprecise and a bad choice of terms) while a carbine (adjustable) stock uses a carbine receiver extension. Along with this, you'll need either a rifle buffer and spring, or a carbine buffer and spring. After you decide which way to go, the rest of the parts are all the same between rifle and carbine builds. The gas system doesn't care which kind of stock you have, and you can have a 16" barreled upper on a lower with a rifle stock, or a 20" barreled upper on a carbine lower.
Hope that helps...