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Ever thought about a 6.5 Grendel? $8.99 a box from AA.
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Yes, but for how long? Wildcat or semi-standardized wildcat cartridges tend to become rare and expensive after just a few years. If you hand load, that is different.
I'll give you two great examples of almost obsolete centerfire hunting cartridges that are technically superior to their competitors, yet have fallen into disfavor and are difficult to find on shelves. The 6mm Remington is superior to the 243 Winchester in just about any measurable way. The 280 Remington is superior to the .270 in just about every way. I own rifles in both calibers and appreciate the benefits. But, I handload. Were I dependent on factory ammo, which used to be very plentiful for each of them, I would have few choices and none that is inexpensive.
On the other hand, standard military ammo is extremely plentiful, available in bulk at attractive price points, and will remain in inventory in good supply virtually indefinitely.
.223/5.56 is going to be with us for a long, long, time, just like .308 and .30-'06. Stick with that unless you hand load., or are adding a unique chambering to an already broad collection of other rifles and don't mind the risk of ammo becoming scarce or obsolete.
BTW: I vote for a RECCE 16" lightweight but precision barrel with 12" free float rail and a QD mounted 1-4 or 1-6 scope with illuminated reticle and true milrad turrets and reticle. Very versatile and easily to carry about. My build is that way except that I deviated by going with a slightly higher magnification scope, a 3-9x40, because I use it more for hunting and not so much home defense. But, I put the scope in a true return to zero QD mount and swap with a QD mounted red dot when the rifle is performing HD duty.