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Good on ya for taking steps in the right direction....and yes BCAAs are fucking magic

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I kind of feel left out that you didn't mention my Brussels sprout recipe.  

I know you're thinking that Brussels sprouts are nasty.  That's because you've only had them over cooked when they develop the sulfur taste and smell.

Try that recipe...I had a request to make them for a Super Bowl party.

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LADA T-1 on an insulin pump and CGMS chiming in.

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Good on ya for taking steps in the right direction....and yes BCAAs are fucking magic

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That's awesome Dan!

Nobelist James Watson proposes an unconventional view of type 2 diabetes causation

A new hypothesis published in the British medical journal The Lancet

Cold Spring Harbor, NY – At 85, Nobel laureate James D. Watson, the co-discoverer of the double-helix structure of DNA, continues to advance intriguing scientific ideas. His latest, a hypothesis on the causation of type 2 diabetes, is to appear 7 pm Thursday US time in the online pages of The Lancet, the prestigious British medical journal.

Watson's hypothesis, which is featured as the Lancet cover story in the U.S. print edition dated March 1-7, 2014, suggests that diabetes, dementias, cardiovascular disease, and some cancers are linked to a failure to generate sufficient biological oxidants, called reactive oxygen species (ROS). Watson also argues the case for a better understanding of the role of exercise in helping to remedy this deficiency.

"The prevalent view of type 2 diabetes," Dr. Watson says, "is that an excess of intracellular oxidation causes inflammation, which in turn kills cells in pancreatic tissue." Proper function of those cells, it is well understood, is critical for the maintenance of normal blood glucose levels.

Over the last several years Watson has been puzzling out an alternative view, based on facts reported in the peer-reviewed literature of medicine and molecular biology. (He makes clear that he is not a medical doctor, rather a student of science.) He does not question that pancreatic tissue in people with type 2 diabetes is indeed inflamed. But he does present a novel theory of why. "The fundamental cause, I suggest, is a lack of biological oxidants, not an excess," he says.

For years, Watson knew, doctors have been telling patients with incipient type 2 diabetes – those with high blood sugar levels -- to exercise, often before putting them on a well-proven glucose-lowering drug regimen such as Metformin. Exercise seemed to Watson the key to the puzzle: what was it about exercise that served to benefit people with high blood sugar?

There were important clues, he speculated, in the chemistry of oxidation and reduction reactions. The body's cells cannot survive without making both oxidants and antioxidants. "There is a delicate balance" between the two, Watson observes. Physical exercise prompts the body to make large numbers of oxidants – molecules called reactive oxygen species, or ROS. In a cellular organ called the endoplasmic reticulum (ER), one such "species," the oxidant hydrogen peroxide (H2O2), helps forge chemical bonds (disulfide bonds) which stabilize proteins as they fold.

When there is not enough oxidation in the ER, Watson says, proteins emerge unfolded, and cannot function. This, he proposes, causes the inflammation that harms the pancreas, sometimes causing type 2 diabetes. Hence, Watson suggests, exercise, which promotes oxidation, plausibly can have a beneficial effect on those with high blood sugar. Such benefit would be lessened if not abolished, he speculates, if such an individual consumed large quantities of antioxidants – just as athletes who take large quantities of antioxidant supplements do not seem to benefit or benefit less from their exertions.

Watson has two take-home messages for his audience. "The first is that we sorely need to take a much more serious and thorough scientific look at the mechanisms through which exercise improves our health." Watson is planning a scientific meeting at Cold Spring Harbor Laboratory later this year which he hopes will launch a larger scientific effort.

There is a second message. "I am not a physician and I cannot offer advice about how people should treat their diabetes; I am advancing a novel idea about how type 2 diabetes can occur. But I also note that just about every doctor I've ever known tells every patient who is capable of doing so to exercise. I think exercise helps us produce healthy, functional proteins. But we really need to have some high quality research to demonstrate this."

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"Hypothesis: Type 2 diabetes as a redox disease" by James D. Watson appears online ahead of print in The Lancet on Thursday, February 27, 2014 at 7 pm ET in the U.S.

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Just did a Bayer store bought A1C test.  While in my experience they run a bit high,  going  actual numbers,  I've lowered my A1C  by over 4 points in 6 weeks.

On 1/15 it was 12.8.
Today,  3/2 it wad 8.7.

I have 6 more weeks until the 3 month mark to get a clean A1C.
For those that don't know, A1C is a rolling 3 month average glucose.  4.0 to 5.6 is the normal range,  with 5.7 t o 6.0 being pre diabetic, and  anything over 6.1 being diabetic.  7.0 is the goal for diabetics to stay at or under.

I have a hell of a lot of problems with the "normal" numbers,  but that's another post.

The important thing is that in theory, continuing my current diet and exercise regimen,  I'll get past that goal and into the actual normal range.

But,  I'm in loss plateau that's stubborn as hell. I  hope to fix that soon.

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Lol been there before. Read your blog post. After I stopped racing bikes and went to bulk back up bench was horrible. I was dying with 135 forever! But finally after about 5 months I was finally back to 225 but man, I struggled with that 135 for a long time. My chest just took forever to start catching up.

Stick with it and it'll all catch up.

Good on the A1c too.

I'm really courious as to what my 1st A1c will be after this type 1 diagnosis and an admitting A1c of 11.1....

My sugars haven't been as good today but I've been sick all day... Not fun... Now add fucking diabetes to the mix and I'm checking my sugars every 2 hours...

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Hey OP, in another thread, you recommended the WALMART brand of blood testers.

Thanks.  Saving a TON on strips.  $.09 vs $1 is awesome.

Recommended to a lady at work and she is switching as well.

Keep up the good work on your own situation.

TXL

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Hey OP, in another thread, you recommended the WALMART brand of blood testers.

Thanks.  Saving a TON on strips.  $.09 vs $1 is awesome.

Recommended to a lady at work and she is switching as well.

Keep up the good work on your own situation.

TXL

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What are your number at waking.