I decided on a whim to take my .300 afield today. I was eager to try out a new hand load and the opportunity presented itself. I did my usual stalk, walking the field roads right at dusk and got lucky. First shot was on a little cottontail. The shot was at about 50 yards and the the 125 grain SMK just lanced right through. Second shot was on a nice sized jack and did some pretty severe damage, also at about 50 yards. Both bunnies were DRT, with only the cottontail giving more than a twitch. Load used was 125 Sierra Match King over 17.5 grains H110 @ 2200 fps. Rifle is my home brew CMMG/Armalite/Daniel Defense mutt (el matacoñejo) topped with a Primary Arms 1-4x.
I don't think I can recommend the .300 for varmints but it was an interesting experiment. If I can ever get my hands on the 110 grain VMax's I may try them as well. I have some loads for the Sierra 125 Game Pro and 110 Varminter on stand by, just waiting on the time to try them out.