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When staying exceeds the risks leaving presents.
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^^^This, and everybody has a different threshold and situation. I have a few scenarios for bugging home from work, but our biggest bug-out threats would be a localized chemical spill (we do have a railroad pretty close), area fire or a significant hurricane that would push directly into us...even with that, I don't see a significant enough threat to leave unless the home itself was going to be destroyed or inhabitable. We don't have family close enough to bug out to, but we have plans for temporary situations. For seriously catastrophic, long term, regional disasters, we will head to my wife's family (closest) or my family (on the other coast); this has to be a nuclear melt-down, massive shift in the fault line that would change the geography or if the region turns liberal-communist blue and I'm at threat of becoming an endangered species.
I think for those attending college; young single adults living/working in a city or a geo-bachelor working away from home need to really consider their bug out plans and threshold. There are any number of situations where travel could be restricted, fuel availability dries up, any type of quarantine, or there is a mass exodus that would clog all routes out. I think for those situations, you really need to define your parameters for getting out of the area before any type of restricted movement or lock-down occurs. This is difficult and it requires some serious attention to news, internet chatter and visible signs in your local area. I would assume the windows to take action would be very small. It's always better to be safe than sorry, so consider having a valid excuse to depart at hand (sick/deceased relative, family member needing assistance or a last minute vacation); missing 3-4 days of school or work is a minor loss if things don't go south, but those few days may make all the difference in the world to get a head start and avoid the traveling chaos or restricted movement scenarios.
For those with a stocked home, they will have a much better chance of staying put and riding out any severe storm or threat. If you don't have a planned bug-out destination you will become a vulnerable refugee once you step out the door.
My first goal is to get home and make sure the family is safe; outside of no home to return to, that's my primary plan with the best chances...
ROCK6