@PistoleroJesse
I like Mystery Ranch for smaller packs (like the 3DAP or smaller Scree or Coulee), but for a serious do all pack, I settled on Seek Outside. I originally planned on just the 4800 Unaweep, added the Gila 3500, and ended up getting a new frame and waist belt to have two separate packs.
The Unaweep is big and with added pockets and top pouch, it's huge. I use for infrequent winter forays where I need the extra capacity for bulkier insulation and winter kit, but it's really too big for any trips under a week. It does compress down pretty good with some modular concepts that I like (removable Merlin back pocket/pack), for a one pack do-all, it's a solid recommendation, but I honestly find it too big for most warm weather backpacking.
I did an 7 day 106 mile hike on the AT with no resupply with just my Gila 3500; I had enough food and fuel for 9-10 days. It's just a little bigger than my ULA Circuit (common AT distance pack), only a few ounces more, but I can stuff it with up to 50 pounds of kit quite easily (normal base weight is only 12-14 pounds) and their hybrid frame system can haul over 100 pounds (if you're a masochist). The suspension system is quite comfortable and their build quality is top notch. Materials are bomb proof and much lighter than Cordura fabrics.
ROCK6