I hunt there often. I don't go to safari outfitters though. I go to the farms of people I know or my own. 7mm Rem is best for longer shots than you'll be taking and really fucks up the meat on shorter shots. .300wm is extremely destructive and fucks up hides bad on things up to about blesbok size. Every time someone uses a 7mm mag or 300 mag over there on something under 400lbs what I end up seeing is shredded hide on the off-side shoulder. .375H&H is fine for very large stuff and will work very well on the smaller stuff too. On smaller things you can shoot behind the shoulder instead of directly into it and it pokes through with usually fairly little pelt damage and it knocks the absolute piss out of kudu/eland/wildebeest/etc... For stuff like springbok, blesbok, warthog, jackal, baboon, etc... up to about 300lbs a 6.5CM or 6.5x55 is about the perfect option really and I've seen large eland taken and kudu with chest shots with a 6.5CM though I personally usually use a .338WM on game from ~400lbs up to about 1200lbs. I've personally taken black wildebeest, waterbuck and an eland with a .308 but those were headshots and you probably will want to take body shots. Pro-tips: Study the anatomies. True antelope are different to deer. African game are ridiculously tough and you want to plant them on the ground because it's actually pretty easy to not be able to find them if they get into a run. I'd just bring a .375 but recoil is a factor so a brake or suppressor is something I would require. I'd also think about a .375 Ruger (I've used one a few times there) if you can get your rifles chambered for that and find ammo for it. Same horsepower as a H&H but not belted and much shorter so longer case life and lighter gun. Also, for a few hundred bucks you can buy a suppressor in ZA (you'll have to work that out long in advance but euroopticafrica.co.za can probably help, I know some of those guys and they're pretty darned helpful) and your PH might have one on hand. Everyone will appreciate you using one. You just need to have the right threading. Ask them about that. I own a few suppressors there. They're not regulated items in ZA, which is funny since I can't have them in Kommiefornia at all. Alternatively, just use a loaner gun while you're there. They'll definitely have the right chambering for the game at hand and they'll almost certainly have a suppressor on it already.