User Panel
User Panel
User Panel
PA, USA
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Posted: 3/29/2024 6:01:08 PM EDT
[Last Edit: macros73]
[#1]
What it cost to make and what it cost to bring to market are both irrelevant.
What are people willing to pay for it? We'll never know given the current and likely future state of medicine. Between employer and government sponsored healthcare, the market signals are distorted enough that we'll never know for sure. If the value is there, let the federal government negotiate a volume discount and make it available for citizens to purchase. |
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Posted: 3/29/2024 6:03:05 PM EDT
[#2]
Quote HistoryOriginally Posted By BobP: What's the cost of the advertising? Just think of the cost of catering for a few of the actors in the commercials. Cut the commercials of fat people acting like they won the lottery. Singing and dancing. That is not reality. |
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Posted: 3/29/2024 6:03:43 PM EDT
[#3]
I saw a headline not too long ago that the company valuation for Novo Nordisk was higher than the GDP for its home country, Denmark.
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Posted: 3/29/2024 6:04:10 PM EDT
[#4]
Quote HistoryOriginally Posted By SparticleBrane: Most of arfcom would go under the desk and fellate a big company's CEO just to prove how capitalist they are. And others on ARF (on this very thread) would do the same to prove what good communists they are. |
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Posted: 3/29/2024 6:04:31 PM EDT
[#5]
Quote HistoryOriginally Posted By SmilingBandit: Wait. Are you telling me that price points vary around the world because what people are willing to pay varies with income? That is effectively what the flat tax people want. |
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OH, USA
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Posted: 3/29/2024 6:07:47 PM EDT
[#6]
Quote HistoryOriginally Posted By BobP: I haven't read the whole article. It may take $5 in material to produce, but that's not the only cost. Profits from one drug will fund current drug costs plus startup cost for other products. What's the R&D cost, which is probably all the article covers. What's the cost of insurance? One lawsuit can be millions, or fairly open ended. What's the cost of the advertising? Just think of the cost of catering for a few of the actors in the commercials. Fuzzy math time. It’s 1000 dollars a month. 9 million prescriptions in the US. Even if they netted 20% of that they’d still be making nearly 2 billion a month. How much was r&d? How much public funding did they get and research grants from universities for this drug? They all take public funding for research. They are the most powerful lobbying in Washington (for their interests not the public’s). You think the hinky shit with Joe Manchin and his pharma daughter is tHe FrEe MaRkEt!!!!….? These are the same companies that lobbied for vaccines mandates. Why the fuck do so many still blindlessly defend them? |
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Posted: 3/29/2024 6:11:35 PM EDT
[#7]
Eisenhower warned us about the "military/industrial" complex . . . Today his warning would be about the "medical/insurance" complex.
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NC, USA
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Posted: 3/29/2024 6:22:31 PM EDT
[#8]
Quote HistoryOriginally Posted By Some_Beach: This. It takes roughly $1 BILLION to bring a drug to market. And that investment has to be recouped during a drug's patent life. Pharma R&D isn't cheap. Patent litigation isn't cheap. Clinical trials aren't cheap. We have a lot of miracle drugs but they come at a price. Lol, patients aren’t paying for that, we are. All this shit is subsidized to some extent. |
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AZ, USA
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Posted: 3/29/2024 6:24:07 PM EDT
[#9]
Nicotine is an outstanding appetite suppressor.
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Posted: 3/29/2024 6:25:21 PM EDT
[#10]
Quote HistoryOriginally Posted By Going_Commando: Someone has to pay for the r&d and FDA approval. If these highly educated fucking morons would realize that new medications and technology don't grow on trees or appear in thin air, then maybe pharmaceutical pricing would make more sense. No one is going to figure out a god damned thing if they don't get paid to do it. If it could've been done for $5, why didn't some benevolent socialist country do it, for zero profit? Oh right, because that's not how reality works. |
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MI, USA
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Posted: 3/29/2024 6:29:36 PM EDT
[#11]
https://www.businessinsider.com/what-is-ozempic-glp1-drugs-developed-by-gila-monster-2023-3 It turns out the venom of a small, Southwestern lizard — the only venomous lizard in America — played a critical role in developing a whole new class of blockbuster anti-obesity drugs, called GLP-1s. One of the newest GLP-1s is called semaglutide. It's sold under the brand names Ozempic and Wegovy — and it is taking Hollywood by storm. Rising demand for these types of drugs, which mimic key hormones that tell us to feel full, have led to severe shortages of GLP-1s in recent months. More at link.  |
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Posted: 3/29/2024 6:34:25 PM EDT
[#12]
Quote HistoryQuote HistoryOriginally Posted By CK187: Originally Posted By JustinU235: Yes a compounding pharmacy can and will make it for you for much less money. The right answer is, "maybe". |
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TX, USA
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Posted: 3/29/2024 6:42:32 PM EDT
[#13]
Patents expire but the US Gov allows them an exclusivity period after the expiration. If the US Gov wants to lower drug prices make sure they can make generics the day after the patent expires. Not sure how much R&D costs actually went into semaglutide since there are/were already similar drugs on the market.
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TX, USA
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Posted: 3/29/2024 7:02:38 PM EDT
[#14]
Quote HistoryOriginally Posted By erud: Exactly. Drug companies are not going so spend millions of dollars and 10+ years of R&D making a product to sell for $5 per month. Quote HistoryOriginally Posted By erud: Originally Posted By runcible: Their property. The price is theirs to set. Exactly. Drug companies are not going so spend millions of dollars and 10+ years of R&D making a product to sell for $5 per month. Ya for newer drugs, this. I work in clinical research and it's insane how much it costs to bring most drugs to market along with the risk should something, despite all the clinical trials, goes wrong and 10 - 20 yrs down the line people end up with something unforeseeable that didn'tcome up during the studies in some small part of the population. We just closed a trial using Ozempic in heart patients looking at if it improves outcomes, not sure on how that will shake out as we only has 22 subjects out of the thousands on the study worldwide , but they all lost weight so that's good for them reguardless. My issue on drug costs is things like epi pens. Old drug off patient since before I was borne. They didn't have to pay for the auto injector technology as that had been developed for the military long before and they charge insane amounts of money for these things simply because they can because it's a life saving item for people with acture anaphylaxis issues. So this thing that can be made for under $30 they were charging what over $600 to $900 at some point for them. I know one person who quit carrying them because of the cost and insurance would not cover. She was a school teacher and simply could not afford to buy them. Even if they charged $60 they would have been making money on them but, nope people have to have it so they screwed people on them. |
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TN, USA
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Posted: 3/29/2024 7:03:09 PM EDT
[#15]
Everybody likes to throw out “free market”. I agree with a free market approach to everything, but the pharma industry is anything but free market. It is an oligarchy with pharma heads populating the FDA and funding a shit ton of lobbyists.
As far as ‘muh R&D’ again justify insulin that was discovered and isolated in the 1920s. The patent holder sold the patent to the University of Toronto for $1 so that it could be cheaply distributed. As a parent who has been buying insulin for three kids with diabetes for over 16 years, i say fuck big pharma. |
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ID, USA
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Posted: 3/29/2024 7:12:43 PM EDT
[#16]
I was listening to a podcast that went on about the company. It has a fascinating history. Nordisc is the original company, one of the first to make insulin from animal pancreases, but the scientists needed more business/manufacturing sense so they brought in a project manager with manufacturing experience. Well this new manager started acting like he owned the business and pissed off the scientists so he was fired. Conversation went something like this:
"You'll never be able to scale" "We'll be fine without you, now get the fuck out". "I'll just go down the street and start making my own" "You!?! You're not smart enough!" And since the danes prohibited patents on medication... he went and did just that starting his new company: Novo. |
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OH, USA
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Posted: 3/29/2024 7:16:19 PM EDT
[#17]
Ozempic is $83 in France. Much cheaper than $1000.
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NC, USA
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Posted: 3/29/2024 7:26:34 PM EDT
[#18]
It's easy to say "The cost of Ozempic is too damned high!" without knowing the cost to research, develop, produce and market their product actually costs them. Same thing when people complain thst an electrician bills them $75 an hour. They aren't taking into account the truck, tools, licensing fees, and insurance he has to maintain to be able to do his job.
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TN, USA
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Posted: 3/29/2024 7:56:22 PM EDT
[#19]
Quote HistoryOriginally Posted By hkusp: Ozempic is $83 in France. Much cheaper than $1000. What's going on isn't capitalism. |
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ID, USA
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Posted: 3/29/2024 8:08:21 PM EDT
[#20]
Quote HistoryOriginally Posted By DarkStar:
https://www.businessinsider.com/what-is-ozempic-glp1-drugs-developed-by-gila-monster-2023-3 More at link. https://pbs.twimg.com/media/GJ3lCuEXUAAeMEH?format=jpg&name=900x900 Quote HistoryOriginally Posted By DarkStar:
https://www.businessinsider.com/what-is-ozempic-glp1-drugs-developed-by-gila-monster-2023-3 It turns out the venom of a small, Southwestern lizard — the only venomous lizard in America — played a critical role in developing a whole new class of blockbuster anti-obesity drugs, called GLP-1s. One of the newest GLP-1s is called semaglutide. It's sold under the brand names Ozempic and Wegovy — and it is taking Hollywood by storm. Rising demand for these types of drugs, which mimic key hormones that tell us to feel full, have led to severe shortages of GLP-1s in recent months. More at link. https://pbs.twimg.com/media/GJ3lCuEXUAAeMEH?format=jpg&name=900x900 Ozempic is not derived from Gila Monster venom and the reporter is either an idiot or is being intentionally deceptive by conflating multiple things. Semaglutide is a GLP-1 agnoist. Terazipatide is a GLP-1 agonist. Exendin-4 shares about half of its structure with GLP-1. Elly Lilly brought the first GLP-1 agonist to the market derived from the Gila Monster venom (can't recall the name). But Novo Nordisk was already working on their own at the time - they just got beat to market first. The original lizard version kinda sucked because it requires getting dosed twice a day to work. Wegovy/Ozempic lasts a week. |
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Posted: 3/29/2024 8:11:33 PM EDT
[#21]
They need to make a profit to cover the inevitable class action lawsuits.
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OH, USA
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Posted: 3/29/2024 8:36:44 PM EDT
[#22]
How many drugs do they pump a ton of money into trying to develop that never produce fruit? How much one pill costs to make is irrelevant.
In fairness, that business is a ton of failures with a few home runs. That can’t be ignored. |
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Posted: 3/29/2024 8:37:56 PM EDT
[#23]
Quote HistoryOriginally Posted By runcible: Their property. The price is theirs to set. |
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Posted: 3/29/2024 8:42:37 PM EDT
[#24]
Quote HistoryOriginally Posted By Going_Commando: Someone has to pay for the r&d and FDA approval. If these highly educated fucking morons would realize that new medications and technology don't grow on trees or appear in thin air, then maybe pharmaceutical pricing would make more sense. No one is going to figure out a god damned thing if they don't get paid to do it.  Attached File Attached File |
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Posted: 3/29/2024 8:54:36 PM EDT
[#25]
Morgan and Morgan did this….
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Posted: 3/29/2024 9:00:10 PM EDT
[#26]
I save $1,000 a month by not being fat and needing that drug in the first place.
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Posted: 3/29/2024 9:01:08 PM EDT
[#27]
I've noticed over the last 40 years that drug cost discussions always hit the "RESEARCH AND DEVELOPMENT COST" wall and ... stop.
I would like to know what's on the other side of that wall. How much research cost? How much development cost? In Dollars. It gets thrown out there like an article of faith and it never gets examined. I know that I have no idea. Fill in the blanks, with numbers, pllz |
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AZ, USA
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Posted: 3/29/2024 9:05:50 PM EDT
[Last Edit: brownbomber]
[#28]
Quote HistoryOriginally Posted By Low-Cap: Everybody likes to throw out “free market”. I agree with a free market approach to everything, but the pharma industry is anything but free market. It is an oligarchy with pharma heads populating the FDA and funding a shit ton of lobbyists. As far as ‘muh R&D’ again justify insulin that was discovered and isolated in the 1920s. The patent holder sold the patent to the University of Toronto for $1 so that it could be cheaply distributed. As a parent who has been buying insulin for three kids with diabetes for over 16 years, i say fuck big pharma. Metformin was discovered or invented around the same time. France approved it in 1957, and the U.S. approved it in 1995 - 38 fucking years later. People who take metformin for diabetes have cancer rates 30-50% lower than the general population, despite typically being fat as shit. Ain't that some shit? |
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Posted: 3/29/2024 9:14:50 PM EDT
[#29]
Look at all the Pharma cucks in here… Jesus Christ, it’s like we haven’t learned anything over the last decade.
That being said, if you’re so fucking fat you need to take a pill because you can’t stop stuffing your face, you deserve to be ripped off… same as buying a Trump Bible. |
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TX, USA
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Posted: 3/29/2024 9:19:05 PM EDT
[#30]
Quote HistoryOriginally Posted By TheWhiteHorse: Look at all the Pharma cucks in here… Jesus Christ, it’s like we haven’t learned anything over the last decade. That being said, if you’re so fucking fat you need to take a pill because you can’t stop stuffing your face, you deserve to be ripped off… same as buying a Trump Bible. It's not just semaglutide. I've been on Eliquis a for few years and it's expensive too. There have been generics already approved but the exclusivity is still keeping them from being marketed. |
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Posted: 3/29/2024 9:22:21 PM EDT
[#31]
The other fat ass drug is available from peptide companies for a tiny fraction of the going price at fat ass clinics.
You know what’s safe and free? Discipline. |
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BHS
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Posted: 3/29/2024 9:26:27 PM EDT
[#32]
Im sure the markup would make even Scrooge blush, but in what universe do drug companies exist making a couple cents per weekly dose? How will they pay for the next 50 experiments, which might not even produce anything marketable? How will they run the FDA approval gauntlet? How will they be able to blanket the airwaves with commercials?
Actually, wait a second… |
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USA
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Posted: 3/29/2024 9:29:24 PM EDT
[#33]
Quote HistoryOriginally Posted By TheWhiteHorse: Look at all the Pharma cucks in here… Jesus Christ, it’s like we haven’t learned anything over the last decade. That being said, if you’re so fucking fat you need to take a pill because you can’t stop stuffing your face, you deserve to be ripped off… same as buying a Trump Bible.  Attached File |
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Posted: 3/29/2024 9:31:49 PM EDT
[Last Edit: Alien]
[#34]
My understanding is that there are a lot of reasons not to take this drug. The cost is the least of your concern. It my understanding is that it paralyzes your stomach, but this effect does not go away for many people and it can cause serious complications.
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USA
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Posted: 3/29/2024 9:33:33 PM EDT
[#35]
Quote HistoryOriginally Posted By AWMCoalition: That's can't cover the R&D cost which is probably in the Billions. It, might, given the demand. But no one figures in the billions of losses on failed projects that never make it to market. |
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MD, USA
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Posted: 3/29/2024 9:33:49 PM EDT
[#36]
The price of a drug has little to do with the cost of its manufacture.
It is all about the cost of clinical trials to prove the claim they make to sell the drug. |
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Posted: 3/29/2024 9:34:31 PM EDT
[#37]
Quote HistoryOriginally Posted By LowBeta: I've noticed over the last 40 years that drug cost discussions always hit the "RESEARCH AND DEVELOPMENT COST" wall and ... stop. I would like to know what's on the other side of that wall. How much research cost? How much development cost? In Dollars. It gets thrown out there like an article of faith and it never gets examined. I know that I have no idea. Fill in the blanks, with numbers, pllz Here is what that R&D cost pays for. Not the 1 drug out 100 that actually works. It also has to pay for the one that works and 99 or more that don't but the company spends hundreds of millions developing. Peoples conception of how science works is literally retard level shit they saw in some hollywood movie. Doesn't work like that IRL, there are no Tony Starks. Science is a slow shitty process where the smartest among the human race fail 99% of the time, but eventually that 1% is what actually moves the needle of the human race forward. And thats why shit costs so much, because you have to cover all the stuff thats failed. Mind you thats with bean counters at every level pinching every penny possible. There are tons of drugs that work great till they get to animal trials and fail horrifically. And then there are the ones that pass animal trials and you get them into humans, and oopsie, massive side effects or deaths sometimes. And by the time you get to human trials your sunk costs on whatever drug are in the hundreds of millions. So thats the reason they have to make big bucks on the very few to pay for all of those that fail. |
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MD, USA
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Posted: 3/29/2024 9:40:50 PM EDT
[#38]
Quote HistoryOriginally Posted By ar15bang: 50% of r&d is paid by us. Show your math/source for that statement. The entire budget of NIH is ~ $35 billion, and only a small part of that is pertinent to development of drugs. In 2019, Pharmacy spent $83 billion on R&D. |
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AZ, USA
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Posted: 3/30/2024 12:31:32 AM EDT
[#39]
Quote HistoryOriginally Posted By entropy: But it is not exactly the same thing. The compounders are using semaglutide sodium. FDA on Semaglutide Sodium Depends on where you go. They can compound the real deal while there is a shortage. When there is not, you must have an "allergy" or intolerance to the commercial form. A lot of places mix B12 with it and charge up the ying yang. |
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AZ, USA
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Posted: 3/30/2024 12:33:55 AM EDT
[#40]
Quote HistoryOriginally Posted By BobP: They actually are partly causing the higher cost in the US. They lobby the companies for free or reduced rate on drugs. Drug companies will donate some drugs to other poor countries. Someone needs to pay for those free drugs. Back when it was popular to go to Canada for cheaper drugs, it came out why drugs were cheaper in Canada. The Canadian government required the companies give them samples, in some cases the asked for formulas. The Canadian government would tell the companies how much they could charge. If the company didn't agree, the Canadian government would produce a generic version of the drug and lock out the originating company. Please ignore conversion rates. Let's say a drug costs $5/unit to produce. To make a profit, the company needs to sell it for $7/unit. Canada tells them to sell it in Canada for $4/unit. The company now has to come up with $3/unit somewhere else to make up for the loss. Guess who pays? Now the US customer is paying $10/unit while Canada pays $4/unit. Cross out Canada and add in civilized countries and less-than. Change your formula according for the latter. |
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USA
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Posted: 3/30/2024 12:39:49 AM EDT
[#41]
Quote HistoryOriginally Posted By TheWhiteHorse: Look at all the Pharma cucks in here… Jesus Christ, it’s like we haven’t learned anything over the last decade. That being said, if you’re so fucking fat you need to take a pill because you can’t stop stuffing your face, you deserve to be ripped off… same as buying a Trump Bible. Spoken like a true Reddit socialist, only you left out "bootlicker". They love to call people bootlickers. It doesn't cost $5 to make and anyone who believes that is fucking illiterate. |
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AZ, USA
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Posted: 3/30/2024 12:44:37 AM EDT
[Last Edit: Beretta_Jerry]
[#42]
Quote HistoryOriginally Posted By SmilingBandit: Good RX shows it for $35/month. How much do you feel it should cost? Regular, NPH, and 70/30 insulin vials ( 10mL, which contains 1000 units ((u-100)) are $25 bucks across the counter at Walmart, no rx needed. Novo rebrands Novolin as Relion and has a deal with wmt. This is essentially '90s therapeutics. The current trend is to start with a basal (glargine/detemir/degludec/many brands and biosimilars with these). If that doesn't dial you in with you other meds, they add a mealtime insulin (aspart/lispro/degludec). The glp1s started with Byetta in the late '00s. It was a daily injection at the time. Interesting fact is derived from Gila Monster (one of two venomous lizards in the world venom.) Now there are many and silly goose celebrities/"influencers" have caused a shortage. The sglt2s are also another new class, though $$. Good news is they show positive benefit for CV and kidney health. Sorry, just read this on dark web wikipedia. 
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Posted: 3/30/2024 12:51:05 AM EDT
[#43]
Pressure? Water off a duck’s back with this industry. They pay Congress too much to get worried about anything. Notice the increase of pharma ads on news channels? Trading advertising money for favorable news stories and no investigative hit pieces.
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AZ, USA
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Posted: 3/30/2024 12:53:58 AM EDT
[#44]
Quote HistoryOriginally Posted By CenterMass762: Are other companies free to produce the medicine and sell it cheaper while still making a profit? If not, that's not very capitalist of us. It usually works like this. The -tides (drugs of the GLP1 class) are currently what I would call a me-too class. A nice example of this is Claritin/loratidine. It sucked, but was reimbursement/cash price 20+ years ago. Beautiful Joan Lunden at the time appeared on the TV ads. Enter Zyrtec. Only difference is it works and <5% of people get drowsy from it. They had the same parent chemical structure, but tweeked it a bit. Manyx87 drugs are like this. Ozempic/Mounjaro and clone sema/triza- are being produced by any different entities. Reputable and less-than websites and former adjective compounding pharmacies as well as clinics. Most buy it from compounding pharmacies, have an NP, and you pay for weekly injections. Caveat Emptor. |
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Posted: 3/30/2024 12:54:31 AM EDT
[#45]
Quote HistoryOriginally Posted By ray9101: Ya for newer drugs, this. I work in clinical research and it's insane how much it costs to bring most drugs to market along with the risk should something, despite all the clinical trials, goes wrong and 10 - 20 yrs down the line people end up with something unforeseeable that didn'tcome up during the studies in some small part of the population. We just closed a trial using Ozempic in heart patients looking at if it improves outcomes, not sure on how that will shake out as we only has 22 subjects out of the thousands on the study worldwide , but they all lost weight so that's good for them reguardless. My issue on drug costs is things like epi pens. Old drug off patient since before I was borne. They didn't have to pay for the auto injector technology as that had been developed for the military long before and they charge insane amounts of money for these things simply because they can because it's a life saving item for people with acture anaphylaxis issues. So this thing that can be made for under $30 they were charging what over $600 to $900 at some point for them. I know one person who quit carrying them because of the cost and insurance would not cover. She was a school teacher and simply could not afford to buy them. Even if they charged $60 they would have been making money on them but, nope people have to have it so they screwed people on them. Quote HistoryOriginally Posted By ray9101: Originally Posted By erud: Originally Posted By runcible: Their property. The price is theirs to set. Exactly. Drug companies are not going so spend millions of dollars and 10+ years of R&D making a product to sell for $5 per month. Ya for newer drugs, this. I work in clinical research and it's insane how much it costs to bring most drugs to market along with the risk should something, despite all the clinical trials, goes wrong and 10 - 20 yrs down the line people end up with something unforeseeable that didn'tcome up during the studies in some small part of the population. We just closed a trial using Ozempic in heart patients looking at if it improves outcomes, not sure on how that will shake out as we only has 22 subjects out of the thousands on the study worldwide , but they all lost weight so that's good for them reguardless. My issue on drug costs is things like epi pens. Old drug off patient since before I was borne. They didn't have to pay for the auto injector technology as that had been developed for the military long before and they charge insane amounts of money for these things simply because they can because it's a life saving item for people with acture anaphylaxis issues. So this thing that can be made for under $30 they were charging what over $600 to $900 at some point for them. I know one person who quit carrying them because of the cost and insurance would not cover. She was a school teacher and simply could not afford to buy them. Even if they charged $60 they would have been making money on them but, nope people have to have it so they screwed people on them. Or she could have just gotten the meds in a bottle and a syringe for $25 and carried that. And not gone the injector route. |
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Posted: 3/30/2024 12:56:16 AM EDT
[#46]
Quote HistoryOriginally Posted By BFskinner: Most drugs are cheap to make. As several have already pointed out it is the R&D, clinical trials and approvals that make them expensive. A pharmaceutical company has to be allowed to recoup those investments or no new drugs will ever again come to the market. No problem from me if it were that simple. My problem with them is selling to other countries with price caps at a loss, then making up the difference by gouging the US market. We don’t have socialized medicine, but we’re damned sure subsidizing it. Capitalism and free market are absolutely a great thing, but that isn’t a free market. |
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AZ, USA
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Posted: 3/30/2024 1:02:16 AM EDT
[Last Edit: Beretta_Jerry]
[#47]
An interesting side note. Ozempic/semaglutide is sold in pens containing 2, 4, and 8mg pens (respective). Based on the article it costs (raw ingredient) $72k/kg, that breaks down to 7.2 cents a mg.
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Posted: 3/30/2024 6:30:13 AM EDT
[Last Edit: BFskinner]
[#48]
Quote HistoryOriginally Posted By Harlikwin: Here is what that R&D cost pays for. Not the 1 drug out 100 that actually works. It also has to pay for the one that works and 99 or more that don't but the company spends hundreds of millions developing. Peoples conception of how science works is literally retard level shit they saw in some hollywood movie. Doesn't work like that IRL, there are no Tony Starks. Science is a slow shitty process where the smartest among the human race fail 99% of the time, but eventually that 1% is what actually moves the needle of the human race forward. And thats why shit costs so much, because you have to cover all the stuff thats failed. Mind you thats with bean counters at every level pinching every penny possible. There are tons of drugs that work great till they get to animal trials and fail horrifically. And then there are the ones that pass animal trials and you get them into humans, and oopsie, massive side effects or deaths sometimes. And by the time you get to human trials your sunk costs on whatever drug are in the hundreds of millions. So thats the reason they have to make big bucks on the very few to pay for all of those that fail. This guy gets it. I am leaving out a few steps but the process goes something like this and usually takes around 8-10 years from start to finish. 1. A medicinal chemist makes hundreds of drugs based off a given structure that they think will interact with a therapeutic target. 2. Structure-activity testing is done and maybe a dozen get pulled out of the pile that have good activity for the target. 3. That dozen drugs then gets tested in in vitro models of safety and efficacy where perhaps a 2 or 3 move forward again, if you are very lucky. 4. Those few that are left get tested in animal models of safety and efficacy where again if you are very, very , lucky one might look promising enough to take into humans. 5. The drug goes into Phase 1 human safety trials (which has nothing to do with efficacy) where it may again (probably will actually) fail due to some off-target effects like prolonging QT intervals. 6. If the drug gets past Phase 1 then it goes to Phase 2 human trials where they actually see if it even does what it was designed to do. Chances are it doesn't, or doesn't do so better than an existing drug so almost every drug that gets here fails despite all the prior work suggesting it would be effective. 7. Then it goes to Phase 3 which is just a bigger and more expensive human trial where it may very well fail. So you win the lottery and you actually end up with a 1 in 10,000 drug you think works better than an existing drug and isn't overly toxic. Now you have to go through the torturous FDA approval process where there is a very good chance that the FDA will decide in the end to reject your NDA (new drug application). If that happens then you bring back more data and try again if the vote was close or you can just give up and start back over somewhere between steps 1 and 4 which are by far the least expensive part of the development process. |
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Posted: 3/30/2024 6:38:25 AM EDT
[#49]
Quote HistoryOriginally Posted By dsteelman: Drug companies ripping people off ? I'm shocked ! They can only do it with willing customers… |
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Posted: 3/30/2024 6:41:15 AM EDT
[#50]
This is nothing new. Same thing decades ago with Bausch and Lambe.
Study or investigation found out a $150 set of contact lenses cots 1/100 of a penny to stamp out. How much in bean cost does Starbucks put into that $4.00 coffee? About 7 cents. It’s actually the highest markup product consumers buy on a daily basis. |
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