I moved from MA to TX less than a year ago. I'm 31 and single, which makes it a lot easier.
I was lucky and my employer doesn't care if I work in Littleton (MA), Ausitn (TX), Lexington (KY), or Raleigh (NC). After spending a week working in the Lexington lab and then a week working in Austin, I decided Austin was the place to go. Spent the week I visited checking out three apartments, touring a shooting range, and checking out the local gunshop.
Got a recommendation for insurance via the TX Hometown forum.
Applied online for an apartment, got accepted, paid first month and deposit with an e-check.
Shipped most of my possessions in a U-BOX (U-Haul's "pod") They take 2 weeks to transport, so I spent two weeks without furniture before I left. Gave away my bed to a friend who wanted it for a guest room.
Packed my truck with my remaining goods on a Wednesday, drove to western MA that night and stayed in a Motel 6. Left 3 AM Thursday and got through CT and NY by 6 AM, then drove across PA (my first free state) before spending the night at a Motel 6 in Ohio. Friday I made it south to Arkansas. Left 2 AM on Friday morning after someone tried to beat down the door to my hotel room*. Got my car inspected Saturday afternoon after I got to Austin, spent one more night in a Motel6 in Austin (where two nasty hookers were going door-to-door)*.
Registered my vehicle 9 AM, and moved into my apartment at 10 AM. U-Haul dropped off my box around 11, and then the professional movers I arranged showed up at noon. Everything was moved in by 2 PM, at which point I stopped by the local RMV to get my TX drivers license, then hit Time Warner to pick up my cable modem (arrangements made ahead of time with them by phone), and I was online by that night.
Took my CHL class on Sunday (arrangements made ahead of time by phone). Got fingerprinted on Wednesday and then mailed my CHL packet the following Thursday.
Bought a bed from IKEA the following weekend. After two weeks on an inflatable mattress, it was nice to have a real bed for a change.
ETA: It took about 3 months of planning between my initial visit to TX and when my truck crossed the boarder into TX.
ETA2: I think my total cost, including the pod, gas, motels, etc. was about $4000. The pods were definitely far easier (and cheaper) than it would have been to do a one-way rental on a truck or trailer, the extra gas, etc..
ETA3: Books on tape rock. I found driving 10hr/day was a good number. I actually really liked the long drive; may take a week off and drive a "circuit" of the western US sometime just for fun.
ETA4: If you have family or friends in the area your headed, that would help. As it is, my closest family is 2000 miles way (except for the guy who escaped a psych ward...no one knows where he is), and my geographically closest friend is about 700 miles away.
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*I'm never staying in a Motel 6 again. I'm also never traveling by car and leaving my handgun in the back of my truck instead of bringing it inside.