Flying into John Wayne? Thats like 5 minutes from my house
What do you like to do? Its all here.
Here are some things off the top of my head:
Downtown Disney has many fun things to do...the ESPN Zone is there, and a Rainforest Cafe, Goofy's Kitchen, and many shops and stores.
Knotts Berry Farm is pretty close.
Newport, Huntington, and Corona Del Mar beaches are close.
The Queen Mary, and Belmont Brewing Co. are just a short drive away.
Discovery Science Center is a few miles south on the 5, if you are bringing kids.
Name a restaurant, and there will be one within a 15 minute drive. Clearmans Northwoods Inn is one of my favorites, and just a few miles up the 5 from D-land.
Angels Stadium is in Anaheim, if you like baseball. I might have extra tix during the time you're here. Let me know.
The King Tut exibit is in LA right now at the LA county musium of art. Thats a bit of a drive, but worthy.
I'll add as I think of other things to do..
Legoland, Sea World, San Diego Zoo, and the Wild Animal Park are all about 1 1/4 hour away in San Diego if you take a side trip.
The Irvine Spectrum has a Dave and Busters, and some really fun shops.