Tritium sights are well worth the cost and effort on defensive handguns IMO for several reasons. For something like a bedside / nightstand pistol, they allow you to quickly and correctly orient yourself to the gun when you may need it in a hurry. If you need such a handgun, you are probably going to need it badly, and you do NOT want to br fumbling with it in the darlk when seconds count.
They also work very well in rapidly changing light conditions, such as when an officer does a traffic stop at night with headlights, strobes, flashing bar lights, shadows, and passing car headlights moving bt, etc. and there is no guarantee that a CCW may not be needed under similar conditions.
Many of us will use only a tritium front blade, leaving the rear sight standard. This cuts the cost in half, and works as well for most circumstances. If you decide to do the install yourself, make sure you have access to a sight pusher or other means for getting the sights on without using a hammer and punch. If you break the vial holding the tritium, they will not warranty the sight.
Of course, you still need a good and reliable source of "white light" for target ID and many other uses.