Do you have cross-dominance eye issues? Make a ring with your hand, and hold it out in front of you as far forward as you can. Find an object in the distance, and look through the ring at it. Now, without moving, close one eye and then the other. One eye will show the object centered (your dominant eye), and the other will not. Does your dominant eye match sides with your dominant/shooting hand?
Any other eye issues?
Are you trying this at the range? At home? Having trouble with just near or just far targets, or both?
A lot of new shooters have trouble learning to focus on the front sight. It's natural to want to focus on the target instead, and some people need practice accepting that the front sight needs to be in focus, even though the target and rear sight won't be.
If you find that you just can't do it, then install an XO same-plane aperture, and use the small one all the time.
-Troy