A Sig P225 would be my first recomendation. She will be able to get her whole hand on it, and as a single stack, it has a thinner profile than the P228.
A Colt Commander (steel frame) would be another good choice. They come in .45, 9mm or .38Super. I'd recomend the .45 of 9mm depending on what she prefers.
Any of the Glocks that are on the 9mm/40 frame are usually pretty grip friendly. I just don't like the grip angle myself.
The Springfield XD/HS-2000 is one to look at. It fits small hands very well, 9mm or .40, and you can legally modify S&W hi-caps for it.
Ross