As stated, first figure out how much per month YOU are comfortable paying.
Get a copy of your credit report. Now is the time to correct errors. Challange any negative reports. If the negative reporter does not respond, it must be removed from your credit report. Your credit report determines the interest and terms of the loan you can negotiate. Negative info costs you big $$.
Then talk to several loan brokers to see how much you qualify for and learn about the different loan options.
A fixed loan is better in most cases. Most buyers are opting for 80/20 loans, meaning no money down. There are pros and cons to each loan product. Shop around. If you are looking for a standard 30 year fixed, a credit union will likely give you the best deal. Get "Good Faith" estimates, and pay attention to every cost. There is no such thing as a interest free, or no fee loan. You pay on the front end, or for the duration.
Shop around for a real estate agent. Find one that is Capable, Professional, and Trustworthy. They all have an agenda, which is to close the deal. However, a good one will look out for your interests somewhat. Don't assume the agent will give you good advice. Don't offer asking price. Look at the asking price, vs. selling price for the "comps" (comparable properties in the area) Don't forget that the selling price usually includes most closing costs to be paid by the seller. (approx 5-8 thousand) You have to specify that in you your contract.
Typically, the buyers agent gets 3% of the purchase amount, paid out of the sellers proceeds. All properties are available to all brokers, so there in no advantage to stick with the big name brands.
Your real estate agent will walk you through the process of making the offer, inpections, deadlines etc.
You will hire an inspector to check out the house, but off the top of my head, I will tell you to look out for Flood zones, water damage, aluminum wiring, termites, and non standard contruction.
Deal only with people who will answer their phone, and are hungry for your buisiness.
Most of the country is overpriced right now, but the Midwest may be the exception. You may actually be able to find something livable, which is also affordable. Don't forget that mortgage interest is deductable, so you get a 15% discount (approx) vs. renting.
Above all, remember: EVERYTHING is negotiable.