Well, I know a crazy dude named Jason Hinkle (moderator and famous has no shame guy over on subguns.com) in Kenai who has a lever action .50 Alaskan, which he then attaches a .50cal suppressor onto...
.50 Alaskan is some serious a$$kicking artillery!
Like the big tiny pistol, eh? Throw that 45/410 derringer away and get the "Alaskan Survival" model - 45-70/.410! Then let me watch you fire it cause I don't want to myself. I have shot quite a few .45-70 revolvers and they were pleasant in comparison to even .454 full house rounds (in the Casull, much nicer in the Taurus)
One thing is for sure, Alaskan's don't shoot each other with tiny little gangsta wussy pistols, we like BIG BORE. I know quite a few women that carry .44 mags. I like it when people belly up to the table and pull their pieces to see who has the biggest hand cannon.