I routinely travel through SC, and when I do, my weapon and holster get moved to my center console as soon as I near the SC state line. I put them back on when I get out of SC. I believe that this is the relevant SC section
SECTION 16-23-20. Unlawful carrying of handgun; exceptions.
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(9) a person in a vehicle if the handgun is secured in a closed glove compartment, closed console, closed
trunk, or in a closed container secured by an integral fastener and transported in the luggage compartment of
the vehicle; however, this item is not violated if the glove compartment, console, or trunk is opened in the
presence of a law enforcement officer for the sole purpose of retrieving a driver’s license, registration, or
proof of insurance;
As always though, verify this on your own...