My S & W 640 Centennial was chambered for +p and (I sold it years ago, idiot) I don't think you could go wrong with it. Like Lumpy said, fires 5 of 5 every time and with plus p's, you are carrying the stopping power of roughly a .357 mag, in a small, internal hammered, stainless piece that won't fail ya.
As soon as my Black Rifle fever goes down a bit, I am gonna have to replace my 640.
edited for typo