Because of so many older, some even black powder designed revolvers chambered in .45 Colt, factory ammo usually is loaded pretty weak. Even so, it's still easily on par with a .45ACP from the factory. Other than not too many loads available for it, the rim of the case is very small, resulting in extraction problems from most DA revovlers. The Single Actions, like the Colt or Ruger use a rod, so it's no big deal there, but on the older New Service and the S&W M25, the extractor star can pass the rim pretty easy. When the Army was using the M1909 (Colt New Service in .45 Colt), they developed a case with a bigger rim, but commercial brass never used it because it didn't fit the loading gate, or the holes were too close in the SAA, or something like that.
It's a great round otherwise though.
Ross