I pick what works....always...first and foremost. Accuracy is relative, mostly to the shooter. Most ammo is easily accurate to 200M when it comes to hitting a man sized target in the chest-the most accurate is not always the best for wounding. That is why I use ballistic gelatin profiles as a REFERANCE and if the bullet is consistant in gelatin (besides what I hear from anecdotal reports) it usually performs well IRL.
But what good is punching a clean accurate hole when, I can have a bullet that may hit a little further away and do significant damage-that makes up for any aiming error on my part or perhaps innacuracy of the bullet? Just my opinion.
As for barrier penetration what is the norm? are you going to be in Africa with 1' thick mud brick walls all around, or in America with paper thin interior walls and thin brick facings. Are you likely going to engage lightly armored vehicles or a car? Are you a civilian going to shoot FMJs that have excessive penetration in your house with perhaps a wife and kid or two, or are you a soldier with more concern with shooting at a fleeting target through a wall? Where do you want to go. As for most humans having a mix of what is accurate has decent penetration and target destruction it is possible to tailor make your needs. The ammo I prefer is not available in the U.S. anymore so I don't write about it-cause I cannot get it anymore but it does for my needs well when I am out of the country and can find it. In the U.S. chances are I am not going to engage armored vehicles and body armor, my biggest barrier to worry about is probably a thin wall or a automotive windscreen-so I will have a small amout of hoarded steel core, A bunch of lead-core FMJ and a decent amount of proven soft point and special purpose stuff that I have picked up in my travels for whatever else. That is the beauty of not having to work under the strictures of the Hague convention-I can pick and choose. Just my opinion