Here's where I think it would be hard. In normal use with an EoTech, you are supposed to look beyond the reticle and focus on the target. When doing so the reticle doesn't seem as pixilated and the dot appears reasonably clear. But when you shift your focus to the dot, then you notice how pixilated it can be.
When using irons at long range, you should be focusing on the front sight, not the target. That's completely opposite of how you use the EoTech. Consequently, I'd be surprised if you could achieve similar results using the EoTech -- if you focus on the dot and let the target go blurry, you are delalng with a pixilated dot, starbusrt effect, whatever you want to call it. If you focus on the target, I'm not sure the dot would have enough resolution. I don't know, I've never tried it, but just using it out to 100 yards, I couldn't imagine using it at long range.