If you have a reason to leave it on, then leave it on. I have a webserver running on my machine, and it's on a cable modem, so I leave it on. I set the power management to turn off the monitor and HDD after a short period when I'm away from the machine so as not to consume too much power.
You're only looking at maybe 100-200W of power consumption. 1KW/H = 1000 watts used for one hour. And 1KW/H costs what, a penny? So running your computer all day might cost you a couple bucks more on your utilities.
If you have no reason to leave it on, then standby is a good option, because resuming from standby is quicker than a cold boot. If you're going to be away from it for a long time, shut it down. If you DO just put it in standby or hibernate, you will want to reboot it after a few suspend/resume cycles.