Eh, it boils down to whatever floats your boat. I currently have a Helix Rack & Control, HX Stomp, a G-System, a Boss VF-1, and some stompboxes. They all have their good and bad points.
Right now, in the band I play in, I use my Helix Rack and Control with a EHX Pog2, and a Duncan 805 in the loops. The Pog is there because the Helix's pitch effects suck. And the 805 is there because, while the drives in the Helix are excellent (the OCD model for instance nails my real OCD V4), it doesn't have an 805 and I like that particular drive a little better than others.
All in all, though, Helix can do everything I need. It's just that I find some of the effects lacking, although for me, they're a bit unnecessary for me at the moment. The reverbs are good, but not great. They're plenty good for a band situation, they just don't do some of the ambient stuff that Strymon, for instance, does better. But that ambient stuff gets lost in 99% of band situations, so the point is moot for me. The aforementioned pitch effects suck, they just don't track well. The rotary speaker effects are ok, but they don't quite do it for me. But like I said, that stuff is kind of bells and whistles for me in my current situation. But beyond that, it's been excellent.
Now, all that said, the Rack is overkill for my current band. And since I've gotten my HX Stomp, I've been playing with it in my spare time, and I'm 99% sure I'll be building a pedalboard around it before too long. That'll let me still use the stuff I like about the Helix and add other pedals to make up for the stuff I don't, without the pedalboard getting too big. So I guess I'll end up with a little of both.