Depends on how much the house is actually worth.
I have clients with houses in the millions, most people I deal with have about 500k equity in their resident.
I highly suggest he approach a reputable commercial real estate company (Sperry Van Ness, Grubb Ellis, Marcus Millichap, CB Richard Ellis) and inquire about buying a property. There will be no cost upfront for anything since the brokers work strictly sell side commission. Of course that money will be paid by him, but only after a deal is done and escrow closes.
Most commercial real estate deal will need at leats 30% down (so just take the equity he has and times 3 and that's the price he can afford) and loan terms of 5-10 years with 30 years amortization.
It's better to buy an apartment complex, shopping center, NNN lease properties as they have a good capitalization rate and high cash-on-cash return. A good investment in the midwest will gross 10%+ cash on cash return per year. Add this with equity build up and debt reduction and your averaging 20%+ returns per year. Generally speaking an apartment building that makes 10% cash on cash return doubles the owner's equity once every 5 years.
If he wants something easy than look into NNN deals, basically the landlord does nothing but take care of the management. The tenant is responsible for the property, utilities, repairs, taxes, insurance, basically everything. This happens when a franchisee of say Arby's want to take his/her equity out of the real estate and invest in another store. You get a decent cash on cash return of usually around 8-10% and long (15+ years) leases.
There are alot of choies, if he is serious contact me and I will offer more advice.