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What isn't "set it and forget it" about VOO? Isn't it essentially an S&P500 managed fund?
(I don't hold ETFs and don't know that much about them, but my impression is that they aren't any less "set it and forget it" than a mutual fund...??)
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The main difference is the ability to buy and sell fractional shares in a mutual fund. With ETFs you can only buy whole shares, so you will always have a little cash hanging around. Similarly you can only sell whole shares.
Mutual funds cand be bought/sold fractionally, so you put $5500 in your IRA you can buy precisely $5500 of a mutual fund.
On the flip side ETFs can be easily transferred between brokerages, while mutual funds can't. Also, when we are talking about non-Vanguard ETFs/mutual funds the ETF will be more tax efficient than the equivalent mutual fund which is important when hold in a taxable account.