Yes, forget H-110, it's for magnum pistol/300 blk.

I've seen it written that 5.0 Bullseye with a 230 gr JRN was the original 45 ACP loading.

Clays in 45 with 200 to 230 bullet is only going to get you to a major power factor of around 167 before you start getting sighs of over pressure.

The powder you are looking for is international clay, which has just a slightly slower burn rate, a flake powder so it easy to get it ignited, and should be able to get complete burns with power factors in the 170's with the can in play.

Take a look at the burn chart, and a good flake powder around the 46 mark should have you in the hunt for a powder that will do complete burn, and still give you the speeds your looking for.  As for spherical powder, it going to meter the best out or a dispenser, but at the same time, the hardest powder to get a ignition on instead.  Do to this, in most cases you want to use a magnum type primer so you do have enough heat to get the needed ignition instead (which also raises the working pressure of the load).

http://www.reloadersnest.com/burnrates.asp

FYI, N320 is right there with Clays for a burn rate (just a nats hair slower), and although I swear by N-320 for match loads to just hit MPF in 40, still come back to clays for 45 target loads for the 45 isntead.

Really, switch over from ball, to a flake type power in the faster burn rate, and should solve the problem on the powder not getting a complete burn before the bullet enters the supressor.

As for blow back, it has a lot to do with the design of the baffles in the supressor.  If using K type barrels, then the pressure is built up one way, and then relieved in the reverse order back through the barrel. Your is not using the through slots on the stacks, so although is going to cut back on some of the blow back, your still going to get some blow back instead.



One last thing, and that you can does a piston to assist the slide unlocking, so make sure your recoil sprung up correctly so the slide is not unlocking back too fast instead when the can is in play.  If you check around, should be able to find a retained recoil system that will allow you to change out the recoils spring  on it.

For the glocks, I just spin up this out of tungston on the lathe to add some weight to the front end, and allows me to change out the spring to one that suits the load on hand better instead.
Gen 3 type show, and on the Gen 4 and later, the end gets the large end piece to go with the larger end of slide channel, then the bolt. As for the spring in play now, its the factory one since it my carry and loaded with full loads, but swap it out with a Wolff reduced spring when I go to range to run lighter target ammo by the ammo can instead.

https://fnamerica.com/products/pistols/fnx-45/