Quoted:
I'm a woman with small hands/fingers and have always had the idea that I absolutely need to reach all controls and operate my pistol well with one hand.
Full sized pistols that work for me. Not necessarily in this order...
1911 with slim grips and short trigger, oversized mag release and extended slide stop
Browning High Power
Followed by most single-stack pistols, though reaching the controls is variable, even within models of the same manufacturer.

Aside from 'full sized' my everyday carry is currently a Springfield XDS 45 subcompact while I transition to my SIG P229 40 which is a compact.
I have both standard and E2 grips, but find the fit better for me with the E2s. I have moved the mag release to the right so I can hit it with my index finger since my thumb is just a bit too short for it to work well on the left.

I also have bilateral carpal tunnel with some hand/wrist weakness which I work hard to overcome and not 'limp wrist' secondary to fatigue.

In the end, you just have to keep your goals in mind when handling weapons and choose what you feel either fits you best or that you can modify to accommodate your needs and desires.


Edit: I also have a Colt Detective Special 38 I've had for years that used to be my primary weapon. I moved to the semi-autos for capacity reasons... that and it's way too pretty to carry.  

Quoted:
You'd be amazed how good a P30 feels in the hand. I use the small inserts on mine and it's great. Incredibly ergonomic pistol.

Quoted:
P99