I don't want a fragmenting OTM round for game I'm going to eat. A 62 or 70gr TSX round would be more ideal I think. A good mushrooming bullet will still ruin a good bit of meat, but less than a fragmenting round.
As far as 5.56 on bear... I wouldn't do it on Arkansas black bear. I imagine an Oregan bear is/could be a good bit bigger. I'd want something with a little more juice per squeeze.