actually, I think the 458 will do surprisingly little.... The vast majority of 458 bullets are overwhelmingly designed as stoutly built deep penetrators. And the impact speeds will be modest. Penetration could likely be measured in yards and feet, but those bullets won't open up really expansively or explosively. You'll get a nice 1 inch hole all the way through the deer, then thru the oak behind it, and then through 6 feet of dirt behind the oak....
the truly awesome (ridiculous?) wounds are cause by speed. Shoot the same whitetail with a very light for caliber, rapid expanding, explosive bullet driven to 3200 fps and kaboommm, its shredded meat. think along the lines of something like a 140 ballistic tip at firewalled speeds out of a 28 Nosler, or a Hornady VMAX at max velocitites out of a 300 Weatherby. It'll get ugly....
Of the dozens and dozens of deer I've killed, one of the farthest running deer with the least impressive wounds was nailed exactly right with a 350 Rem Mag shooting 225 grain nosler Partitions at just under 2700 fps. Again, tons of deep penetration coupled with limited expansion. Wounds are surprisingly narrow.
A buddy also used 375 H&H extensively on deer. In most cases, its a deep penetrating bullet at speeds of what, 2700-2800 fps? In other words, a vary large scaled up 30-06 with a 180 grainer. The typical 150 remington corelokt or win powerpoint makes a bigger mess.
The killing power of big cartridges at modest speeds (2600-2800 fps) is based on del penetration. they kill BIG critter reliably, but don't make huge messy gaping wounds (that would run contrary to the design intent of the cartridge). The huge gaping wounds (which, when you think of it, are really stupid) are caused by lightly built bullets at reply high speeds.... instead of expanding, they explode.
Using a light for caliber bullet, designed for slow impact speeds and then driving them 300, 400 or more feet per second faster, pushes bullets beyond their design limits. An extreme example would be using 45 colt hollow points in something like a 45-70 or 458. Or using 158 JSP for 357 pistols in 35 Rem. You are now into explosive bullet territory. Expect a very wide but very shallow wound, complete shoulder loss, and a real waste.
Your 300 HP in the 458 will be similar. This sounds counter intuitive, but you'll act sully get BETTER performance if you load that bullet to slower than 458 speeds. If its designed for 45-70 speeds, and its driven too hard, it will not do well. If you cut back the muzzle velocities so you are shooting at high end 45-70 speeds (sort of a 458 lite), you'll do fine.