Well, in 8 years in AZ, I crossed paths with exactly 1 rattle snake. (poor ending for snake). Coyotes kept their distance on hikes. Tarantulas were pretty harmless. Had some large spiders and centipedes.
Read this morning a lady got killed by an alligator around Beaufort! I think same thing happened last year near there. Walking her dog!
In summer I carried a ruger lcr with a couple snake shot rounds in it walking the dog. Might have to up the hardware I guess.