Callgood: I've never done any 10mm reloading. I have done a lot of shooting @ 100 yds. with my Glocks, though. Best groups I ever shot were shooting .40 Super, which is similar in ballistics to 10mm. I use AA#7, exclusively, for .40 Super; I understand that Accurate Arms recommends AA#7, above their other powders, for 10mm reloading.
I plan to get a KKM .45/10mm conversion barrel, probably threaded, for comp use, in the not-too-distant future. I'll get some 10mm dies and do a little reloading when that happens. Colorado Glocker, on GT, is doing a lot of experimenting with his G21 longslide, equipped with a 6" 10mm KKM conversion barrel. He's claiming some pretty good groups; don't know if he's doing any 100-yd. shooting, or not.
One thing I would recommend, if you're not already doing it, is using the Elmer Keith method of sight picture acquisition for long-range handgun shooting. I hold @ 6:00 o'clock, and simply raise the front sight to compensate for longer ranges. That way, you always have a clear view of your target, and the front sight width is inconsequential. Some folks think that a thin front sight is necessary for long-range handgunning. Not so. A thin front sight will allow for quicker target acquisition, in that you'll see more daylight around the sight, but that's irrelevant to long-range shooting. Every front sight has an infinitely-narrow centerline; use it.