The Python and King Cobra are totally different guns with nothing in common other than the Colt name.
The Python is a hand built, semi-custom gun that was intended to be the finest DA revolver ever made. It's legendary for it's accuracy and smooth trigger. Like an Italian sports car, it has to be treated properly and needs occasional tune ups to keep it in proper working shape.
If it was a car, it'd be a Rolls Royce.
The King Cobra was a mass-produced revolver that required little hand fitting. It was intended to be about a step above the other brands, but still a popular priced gun. It's usually noted for above average accuracy, and is probably the strongest medium framed DA revolver ever made. It's only "weakness" is that you need to use snap caps for dry firing to prevent any chance of a broken firing pin. A broken pin is a factory level replacement ONLY.
It was designed for unlimited use with full power .357 ammo, and seldom gives trouble.
If it was a car, it'd be a Hummer.
If you shop around, you can usually find a Python shooter for prices starting around $800.