As an east-coast guy (mostly Florida and Virginia, some time in Maryland) every time I go out West I feel like a different human. I have LOVED Colorado, Wyoming, & Montana. I would probably put Alaska as a big destination, and in the mean time I am planning a trip that involves Sedona, Grand Canyon, Monument Valley, and Moab, flying into Phoenix and out of Grand Junction.
Internationally - I have done some Europe (but not nearly enough), and ZERO Asia.
I would be happy selling almost everything we own to fund more adventures, especially with the kids. Whenever we travel, my 6 & 8 year olds have their own P&S digitals. We get some cool pictures that way, and they are very curious about making their pictures better.
-shooter