New Drug Acts as Marijuana in the Brain
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New Drug Acts as Marijuana in the Brain December 14, 2005 9:13AM
"This is the first time it has been shown a drug that increases endocannabinoids in the brain can improve your mood," said lead investigator Dr. Gabriella Gobbi, a researcher at Montreal and McGill Universities. The researchers were able to measure serotonin and noradrenaline activity as a result of the increased endocannabinoids.
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A McGill University study suggests a new anti-depressant drug works by raising levels of endocannabinoids -- similar to a substance found in marijuana.
The study suggests the new drug, called URB597, might represent a safer alternative to use of marijuana for treatment of pain and depression, and open the door to new and improved treatments for clinical depression.
In pre-clinical laboratory tests researchers found URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable anti-depressant effects.
"This is the first time it has been shown a drug that increases endocannabinoids in the brain can improve your mood," said lead investigator Dr. Gabriella Gobbi, a researcher at Montreal and McGill Universities.
The researchers, including scientists from the University of California-Irvine, were able to measure serotonin and noradrenaline activity as a result of the increased endocannabinoids.
"The results were similar to the effect we might expect from the use of commonly prescribed anti-depressants, which are effective on only around 30 percent of the population," said Gobbi. "Our discovery strengthens the case for URB597 as a safer, non-addictive, non-psychotropic alternative to cannabis for the treatment of pain and depression."