I have two dedicated 22 uppers (both Kuehl), one spends most of the time on a Colt M16A1 & the other on a Colt AR-15. Most of the time, with an SRT Comanche suppressor. They are near 100% with CCI subsonics & anything hotter right out of the box. Lower velocity subsonics don't reliably eject. These uppers are about chipmunk accurate at 50 yards. That being said, I have 3 10/22s, one a full auto Norrell. The Norrell has an integrally suppressed barrel designed to slow supersonic rounds to subsonic. This only works well with high velocity ammo. 100% with CCI minimags. The other 10/22s have Green Mountain barrrels. Accurate, but with the Bentz chambers are very mag sensitive. So far, I've only gotten the stock Ruger mags to work well. The stock 10/22 barrels are generally not very accurate & the chipmunks love them. Although some folks claim exceptions, I wasn't satisified at all with the stock barrels.
If I could have only one, it would be an AR-15/M16 with a Kuehl upper. Plenty accurate, high fun factor and evil looking. Also, easy to slap on a 5.56 upper if you want to be loud or take on something larger than chipmunks.
ps - I have nothing against chipmunks unless thay are tearing things up around the yard.