Finally a question I am qualified to answer...
I kill a lot of hogs with everything from .22LR to 45-70, .375H&H and .470 Capstick. You can blow large holes behind or in the shoulders if you have GOOD bullets in a medium to large caliber, but thats no gauranty.
I've seen 'em run from hits with everything you can imagine, with holes big enough to see the sunrise through...I have broken down both front shoulders on 300 pound hogs at 15 yards with rifles whose names make Elephants nervous, and watched 'em run off.
But I have never lost one (or watched one run) if I hit it in the ear or behind the jaw or at the base of the skull. Broadside shots only, a frontal head shot to the forehead will likely deflect.
Can you shoot well? Then stick it in their ear and have a good time. Bullet design matters not.
Greetings from Texas,
KMJ