I use the 6 o'clock hold for high power. The reason is because that is how I have always shot round targets. With clean sights or with sight black, I lose the top of the post in the middle of the black. With carbon smoker, it is MUCH easier to see the post.
I don't have a smoker yet. The guy I shot with at Pendleton this year had one that he let me use. Once I get the smoker I am going to try moving to the center mass hold. Some of the great shooters that I talk to recommend it based on two points.
First, it helps with the mental game that your sight is in the middle of the black no matter what. Over time and with practice, the amount wobble should become less pronounced and this mental boost of sight picture (front post always in black) helps with breaking the shot more smoothly.
Second, point-of-aim-point-of-impact shooting is preferred for other scenarios such as hunting and 3-gun. By knowing your exact sight dope for POA-POI, there is no working out the right come-ups outside of high power.
Obviously the change in elevation from 200 to 300 to 600 is the same amount. The difference is the height between the bottom of the black and the middle.