Do this: find the minimum and maximum load for your powder/bullet combo. I wouldn't necessarily start at the minimum, maybe 2 grains into it (i.e., if min is 40grs and max is 45, I'd start at 42 or so). Load one round at 42.2, then 42.4, 42.6, basically, adding .2 until you get through to your max. Strap a chrono on the end of your rifle and go shoot the rounds. Wherever you find a small variance in velocity, exploit that charge weight.
Example:
42.0 - 2700
42.2 - 2710
42.4 - 2718
42.6 - 2722
42.8 - 2723
43.0 - 2742
The change in velocity between 42.6 and 42.8 only added 1fps. With that info, you'd probably want to load 10-20 rounds at 42.7 and see how they shoot. Adjust seating depths after that, because if you have a capable rifle, I would almost guarantee that load will perform very well.
Scott Satterlee developed this method and it has worked amazingly well for me. It is so damn easy and has proven very effective.
Another note is the simple fact that you may find multiple nodes in your load string. With my last rifle, I had three different nodes, so I loaded up 10 rounds of each (seating just .020" off the lands) and each load shot sub-half minute. Kind of cool because it gives you some options, I suppose, but then again, one of those loads put a 5 shot group at .18" and I am not the best "group" shooter, either.
Scott, if you're reading this, thanks again. His method has made finding a load super easy.