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Not legally without a license, simplex or not. Falls under automatic operation of part 95 equipment.
Easiest/lowest-cost is GMRS which allows up to 50W repeater. The cheap-shit FRS/GMRS radios don't do split, but the decent ones will. My Garmin Rinos have a switch in the menu to enable the GMRS repeater channels. Pretty sure the higher-end T-series talkabouts do this as well.
FRS, MURS, CB... nope.
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I just searched for any Part 95 radio services' bans on repeaters. While MURS bans repeater stations, the prohibition in the FRS subpart is only of data packet repeaters, not voice. And I'm not finding any prohibition of voice repeaters on CBRS.
https://www.law.cornell.edu/cfr/text/47/95.2733
95.2733
Prohibited MURS uses.
MURS stations must not be operated as repeater stations or signal boosters. This prohibition includes store-and-forward packet operation.
https://www.law.cornell.edu/cfr/text/47/95.587
(d) Packet mode. FRS transmitter types must not be capable of transmitting data in the store-and-forward packet operation mode.
If they won't even let you operate at the control point of your repeater the whole time it's in use, it seems redundant to put in these extra specific prohibitions against repeaters...