I've had great success with the Hornady 250gr FTX. This is the fourth season I've used it, and it has yet to let me down.
This year I shot a nice eight point buck that was walking in, I had just walked into the woods and shot him from standing at about 35-40 yards. It blew through his left front leg, the top of his heart, and part of a lung. He leapt as soon as it hit him, landed, then dropped.
The past three seasons before I took nice doe. One was a bad shoulder shot on my part, she ran 30 yards and dropped. Next one was a double lung that blew all the way through (major blood trail), she still ran 20 yards. Last was one that folded up right where she stood. I can't remember where I hit that one.
Before I moved to the 450 bushmaster, I was shooting Hornady SSTs out of my 12GA. They also did really well for me, and the FTX projectile looks very similar to the one in my SST 's.
I have mine zeroed at 35 yards, which gives me the least amount of deviation from POA out to 250 yards. I'm using a Franklin Armory 14.5" barrel with pin/welded FA comp, and it's a hammer. Very accurate, and so easy to wield. For optics, I'm using a Nikon M223 1.5-6x scope.