Posted: 4/27/2023 9:04:54 AM EST
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The late-stage study of the drug for weight loss adds to earlier evidence that similar participants without diabetes lost up to 22% of their body weight over that period with weekly injections of the drug. For a typical patient on the highest dose, that meant shedding more than 50 pounds. Industry analysts predict that tirzepatide could become one of the top-selling drugs ever, with annual sales topping $50 billion. It is expected to outpace Novo Nordisk’s Ozempic — a diabetes drug used so commonly to shed pounds that comedian Jimmy Kimmel joked about it at the Oscars — and Wegovy, a version of the drug also known as semaglutide approved for weight loss in 2021. Together, those drugs made nearly $10 billion in 2022, with prescriptions continuing to soar, company reports show. https://apnews.com/article/mounjaro-wegovy-ozempic-obesity-weight-loss-bd0e037cc5981513487260d40636752a |
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It supposedly works extremely well. My girlfriend is a plastic surgeon & general surgeon. It’s prescribed a lot more now to patients that can’t have surgeries due to weight. So that they can quickly cut weight down to have the surgery. I guess the problem, as always, is life style changes once you go off it. Unless you correct your life style, it’s never going to work forever. |
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Show me—medication induced pancreatitis! ETA: I should have kept track of all the big pharma claims in my 30 years of medicine/surgery. Some highlights: Hormone Replacement Therapy for post-menopausal women won’t increase breast or ovarian cancer risk—except for when it does; OxyContin is the best post-op pain management medication with little risk of addiction or abuse; Phenmetrizine is a safe weight loss medication, except for the heart valve damage; My instructors remembered Demerol & Valium were non-addictive & quaaludes allow on-call doctors to sleep, wake-up clearly & care for patients without possible side effects….until it went Schedule 1. |
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It works great at treating the symptom and not the disease. Eventually it stops working or they cant afford it anymore and they gain all the fat back, but none of the lean mass or bone density they are losing at an alarming rate. 40% of weight lost on semiglutides is lean muscle and bone density. |
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Quoted: It supposedly works extremely well. My girlfriend is a plastic surgeon & general surgeon. It’s prescribed a lot more now to patients that can’t have surgeries due to weight. So that they can quickly cut weight down to have the surgery. I guess the problem, as always, is life style changes once you go off it. Unless you correct your life style, it’s never going to work forever. Can you go off of it? My understanding was that it requires weekly injections and getting off of it could be very bad. |
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Yay keep stuffing your face so you can spend $500/month on drugs for the rest of your life. Start just skipping breakfast. See how long you can wait before you are actually hungry. Stop snacking on garbage. Cut out soda and beer. Any one of those would work wonders for a lot of people. |
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Quoted: Can you go off of it? My understanding was that it requires weekly injections and getting off of it could be very bad. Quoted: Quoted: It supposedly works extremely well. My girlfriend is a plastic surgeon & general surgeon. It’s prescribed a lot more now to patients that can’t have surgeries due to weight. So that they can quickly cut weight down to have the surgery. I guess the problem, as always, is life style changes once you go off it. Unless you correct your life style, it’s never going to work forever. Can you go off of it? My understanding was that it requires weekly injections and getting off of it could be very bad. I am *not* a medical expert at all. I’m just repeating what I’m told. If you’re non-diabetic and just taking it for weight loss, you can go off it. If you’re diabetic, and you go off it, problems can happen. It was explained to me, it basically just artificially induces the full feeling hormone. So you naturally eat less. But again, I am absolutely not an expect. |
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Quoted: I've been on Trulicity for a couple of years. Let me tell ya, somedays , the side effects SUCK. Hasnt helped with weight in years, but it does help even out my BS. It's fun when your intestines decide randomly that you should be able to shit through a screen door for a couple of days. |
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Quoted: Yay keep stuffing your face so you can spend $500/month on drugs for the rest of your life. Start just skipping breakfast. See how long you can wait before you are actually hungry. Stop snacking on garbage. Cut out soda and beer. Any one of those would work wonders for a lot of people. You get hungry like you normally do, that doesn't change when you fast. |
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Quoted: I am *not* a medical expert at all. I’m just repeating what I’m told. If you’re non-diabetic and just taking it for weight loss, you can go off it. If you’re diabetic, and you go off it, problems can happen. It was explained to me, it basically just artificially induces the full feeling hormone. So you naturally eat less. But again, I am absolutely not an expect. This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little. |
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Quoted: This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little. Quoted: Quoted: I am *not* a medical expert at all. I’m just repeating what I’m told. If you’re non-diabetic and just taking it for weight loss, you can go off it. If you’re diabetic, and you go off it, problems can happen. It was explained to me, it basically just artificially induces the full feeling hormone. So you naturally eat less. But again, I am absolutely not an expect. This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little. So it's meth |
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This is ridiculous. The cure for being fat, lazy, and weak minded is to eat real food and exercise. Offering a medication instead of exercise and a healthy diet is not addressing the actual problem. People will use the medication, continue their shitty life choices and keep the Pharma companies flush with cash. But, we all know that's the plan, right? |
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Quoted: I heard that these drugs have to be taken forever. If one stops taking it, instantly fat again and very unhealthy. Also, I thought being a fucking beached whale was healthy and popular now A quick google search, says this is false for weight loss. You can go on and off it, but it’s not recommended. There is a lack of long, long term studies on weight loss. The longest study was 68 weeks on the drug before going off. Short term studies have shown the yo-yo affect, because people don’t want to change life styles. |
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Quoted: Yay keep stuffing your face so you can spend $500/month on drugs for the rest of your life. Start just skipping breakfast. See how long you can wait before you are actually hungry. Stop snacking on garbage. Cut out soda and beer. Any one of those would work wonders for a lot of people. I've lost 40+lbs since Feb doing this, down from 230lbs. I don't eat before 12 and don't eat after 7. No regular sugar in my diet, and I eat primarily meat and veggies.i can and do cheat, but it's a treat and not a regular facet of my diet. Not eating before noon and after 7 is the biggest deal, since you can effectively convince your body you don't need to eat at those times and it has no choice but to eat fat. No more hunger sensation, either. |
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Quoted: A quick google search, says this is false for weight loss. You can go on and off it, but it’s not recommended. There is a lack of long, long term studies on weight loss. The longest study was 68 weeks on the drug before going off. Short term studies have shown the yo-yo affect, because people don’t want to change life styles. Quoted: Quoted: I heard that these drugs have to be taken forever. If one stops taking it, instantly fat again and very unhealthy. Also, I thought being a fucking beached whale was healthy and popular now A quick google search, says this is false for weight loss. You can go on and off it, but it’s not recommended. There is a lack of long, long term studies on weight loss. The longest study was 68 weeks on the drug before going off. Short term studies have shown the yo-yo affect, because people don’t want to change life styles. Interesting. So there's no such thing as a magic pill. You have to actually work and commit in order to stay healthy. Huh, weird. Maybe people should do that from the get go, exercise and eat healthy, rather than look to the pharmaceutical industry for a cure to a self inflicted problem. |
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Quoted: Phen phen. Of fenfen? Don't remember how it's spelled but it killed my dad's friends wife back in the 90s Quoted: Quoted: How long until they discover it will kill you in 20 or so years? Or do they already know and it's a feature, not a bug? Phen phen. Of fenfen? Don't remember how it's spelled but it killed my dad's friends wife back in the 90s |
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Quoted: Interesting. So there's no such thing as a magic pill. You have to actually work and commit in order to stay healthy. Huh, weird. Maybe people should do that from the get go, exercise and eat healthy, rather than look to the pharmaceutical industry for a cure to a self inflicted problem. Quoted: Quoted: Quoted: I heard that these drugs have to be taken forever. If one stops taking it, instantly fat again and very unhealthy. Also, I thought being a fucking beached whale was healthy and popular now A quick google search, says this is false for weight loss. You can go on and off it, but it’s not recommended. There is a lack of long, long term studies on weight loss. The longest study was 68 weeks on the drug before going off. Short term studies have shown the yo-yo affect, because people don’t want to change life styles. Interesting. So there's no such thing as a magic pill. You have to actually work and commit in order to stay healthy. Huh, weird. Maybe people should do that from the get go, exercise and eat healthy, rather than look to the pharmaceutical industry for a cure to a self inflicted problem. I lost 120lbs. Don’t gotta tell me. I gained 20 back because I herniated S1/L5, bulged a few other disks up. Now working on dropping it again. I do get the idea for people that are sorta “too far gone.” I.e. morbidly obese people that need surgery, to be able to do anything. But without major life style changes, won’t help. |
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Quoted: In five years they'll be thousands of television commercials from law firms. If you've taken the drug and experience, cancer, heart problems, or any other problem, give us a call. Did you take a weight loss drug and now have uncontrollable rectal bleeding? You may be eligible for compensation |
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Quoted: So it's meth Quoted: Quoted: Quoted: I am *not* a medical expert at all. I’m just repeating what I’m told. If you’re non-diabetic and just taking it for weight loss, you can go off it. If you’re diabetic, and you go off it, problems can happen. It was explained to me, it basically just artificially induces the full feeling hormone. So you naturally eat less. But again, I am absolutely not an expect. This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little. So it's meth Yeah, but without the fun. |
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Quoted: Because playing fuck fuck games with one's endocrine system sounds like a great idea. Doesn’t work on just endocrine system, works on GI too. In the grand scheme of things many other DM drugs work similarly but the GI effects to slow transit is what keeps people felling full and eating less. Regardless you are way behind investing in pharma if you haven’t already cause there are still more to come out and it’s gonna be very large market for these. |
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Quoted: Show me—medication induced pancreatitis! ETA: I should have kept track of all the big pharma claims in my 30 years of medicine/surgery. Some highlights: Hormone Replacement Therapy for post-menopausal women won’t increase breast or ovarian cancer risk—except for when it does; OxyContin is the best post-op pain management medication with little risk of addiction or abuse; Phenmetrizine is a safe weight loss medication, except for the heart valve damage; My instructors remembered Demerol & Valium were non-addictive & quaaludes allow on-call doctors to sleep, wake-up clearly & care for patients without possible side effects….until it went Schedule 1. All true…but…. The people taking this drug are most likely MORBIDLY OBESE. It shouldn’t be prescribed to anyone else. Morbidly obese people who need to lose 100lbs instantly are already on a trajectory to a short life anyway. |
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Quoted: What are the long-term impacts? Not known? It will be. Quoted: Quoted: It's all the rage right now with the good looking soccer moms. I know tons of people on it... and they're all a lot skinnier now. It sounds like a miracle drug so far. What are the long-term impacts? Not known? It will be. No clue. Hopefully fewer impacts than people staying fat. |
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I've been on a couple of GLP-1 agonist drugs, Victoza, Trulicity, Ozempic, etc. for the type 2 'beetus. Super bad maternal-side genes for shitty insulin receptors is our curse. Both maternal grandparents, aunts, and my mother, now me. None are or were significant fatties. No side-effects for me from using it, nor from going cold-turkey on them several times for months + because I can't find the stuff to fill my Rx as the fatties are all bum-rushing their doc to get them. My average bg mg/dl gets noticeably worse, and the Metformin and supplemental insulin, and Jardiance coaxing my kidneys to pee away excess glucose doesn't pick up the slack. Pancreantitis or actual Pancreatic cancer is a shitty way to die, but if you've got type 2, or are just a fatty, that'll kill you too. Just a matter of how fast, and the eventual odds. And GLP-1 agonist odds are way lower. Plus "you or a loved one" can't sign onto a class-action advertised on late-night TV a decade in the future, and maybe get a check for a few thousand bucks for type 2 'beetus, or for being a fatty, as there's nobody to sue. Granted, the modern American diet & lifestyle with a big predominance of HFCS & bleached processed starch in a box/bag containing as much air as possible, because it's most amenable to industrial economy-of-scale.... Then combined without a job of back breaking labor 7/365 in a farm field, and the automobile, etc. ain't helping. And going all Uncle Joe & Mao to fix that from beginning to end, kinda creates a "national weight loss program" for everybody, if they need it or not. Bernie bitching there's more than 2 brands of armpit sticks is bad enough. And from the Tumblr/Reddit types that bitch about fat-cats & "failures of capitalism", mainly because their liberal arts degree, six-figure student debt, and Starbucks job didn't gain them sufficient economic utility to have a BMW & McMansion... that sort of thing doesn't require conspiracies. It's just a bunch of "path of least resistance" kind of stuff. And eating kale and a chicken breast, and not settling off the "lunk alarm" at Planet Fitness is kind of a PITA. And your bg going way over 200 mg/dl anyway, when all you did eat was that damn 8oz chicken breast & kale for dinner, is discouraging. So the shots it is. |
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They work. My wife and a good friend are both taking Mournjara. In 3 months, one lost 50lbs the other 30. My wife is now having some digestive issues. Not sure if it is a side effect. Docs trying to find out. Others are reporting gall bladder stones and issues. Too early to tell. Lose the 30, then quit. |
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