Well lets look at what would go in a safe,
Metal, the dryer the better. I treat the outside of my guns with Birchwood Casey Barricade, and they stay in like new condition.
Wood( Like a rifle stock) Is either sealed or oil finished. so if the stock is able to take in moisture it will swell.
Leather, leather doesn't get stored in a safe. Again it should be treated with a product such as the stuff Galco sells to keep it conditioned.
Also stay away from products like saddle soap , they will soften and weaken leather over time.
Ammo, ammo should never be stored in a gun vault. In case of fire the safe will contain ammo pressure to a point and then the vault will explode. So it's like having a atomic bomb in your gun room.
So short story is the dryer , the better. I cringe when people even talk about putting a humidifer in the same room as the vault.
Now if you don't belive me, do some searching and many people put their vault in the basement and there are numerous horror stories of rust on the internet.