Big handles? That typically implies a big folder and while the Super CQC7 has a bigger handle, the blade is only about 3.75". Some are more efficient with handle to blade ratio, but just wondering if you're more concerned with the handle than the blade size.
I really like the larger Hogue X5, although their handle is not very conventional; I still like the design. Spyderco's 100-Pacer is a large, thin handle, much like the Military model. Benchmade Adamas is a handful and Benchmade's Bedlam has a pretty large handle as well.
If you want "really" big, you can step up to the ridiculous folder category
Not really "pocket" EDC knives though, but they do fill the hand quite well!
Fox Knives has a couple I'm interested in, both with larger handles:
Desert Fox:
Col Moschin:
Just some options around the same price range...
ROCK6