Well, I cast my own bullets and like shooting black powder, but I prefer the original WCF cartridges because their thin brass seals the chamber better than .45 Colt. I've read where some CAS shooters using BP in .45 Colt will fireform .44 WCF brass in their rifle's chamber and then load them as .45 Colt. The thinner brass seals the chamber well and keeps fouling out of the action.
If you don't want to mess with that then stick with smokeless under regular cast bullets, or plated or powder coated bullets. Slower burning powders will help you maximize velocity from the rifle barrel.
In .38 WCF and .44 WCF, Alliant used to list data for Reloder 7. E.g., in .44 WCF 23.5 grains of Reloder is 7 under a 240 grain bullet should give ~10% boost over a full BP load, but at pressures that are safe for use in black powder rifles (13,000 CUP). And according to C.E. Harris, you can't get enough Reloder 7 into a .44 WCF case to cause dangerously high pressure. There might be a similar load you could use in .45 Colt. See this page and especially the post by John Kort. He did a lot of research on the use of Reloder 7 in .44 WCF:
https://www.shootersforum.com/threads/the-paco-kelly-45-colt-rel-7-load.51372/Otherwise, you should be able to get good results with powders like Unique, Herco, or H-110.